Pengaruh kurangnya jumlah jam tidur terhadap perubahan kadar gula darah pada mahasiswa preklinik Fakultas Kedokteran Unika Atma Jaya

Authors

  • Zita Arieselia Fakultas Kedokteran Unika Atma Jaya
  • Yenna Tasia Fakultas Kedokteran Unika Atma Jaya
  • Poppy Kristina Sasmita Fakultas Kedokteran Unika Atma Jaya

Keywords:

aktivitas sistem saraf simpatis, kadar gula darah, kortisol, kurang tidur, leptin

Abstract

Pendahuluan: Kurangnya jumlah jam tidur adalah suatu hal yang wajar bagi masyarakat zaman sekarang dikarenakan mereka ingin memaksimalkan waktu mereka untuk dapat melakukan semua aktivitasnya. Sementara itu tidur diperlukan untuk mengembalikan proses biokimia atau fisiologis yang menurun ke keadaan semula. Terdapat beberapa penelitian yang menunjukkan bahwa kekurangan tidur kronis dapat meningkatkan risiko obesitas, penyakit kardiovaskular, dan peningkatan kadar gula darah, yang dapat berlanjut menjadi diabetes mellitus tipe 2.

Tujuan: Penelitian ini merupakan studi pendahuluan untuk mengetahui efek berkurangnya jam tidur terhadap perubahan kadar gula darah.

Metode: Mengukur kadar gula darah puasa dan kadar gula darah 2 jam setelah oral glucose tolerance test (OGTT) pada 18 mahasiswa preklinik Fakultas Kedokteran Unika Atma Jaya dalam keadaan cukup tidur (7 jam atau lebih) dan kurang tidur (kurang dari 7 jam) selama 2 malam. Data dianalisis menggunakan uji T berpasangan untuk melihat apakah kekurangan tidur selama 2 malam menyebabkan perubahan pada kadar gula darah puasa dan kadar gula darah 2 jam setelah OGTT.

Hasil: Kadar gula darah puasa dan kadar gula darah 2 jam setelah OGTT meningkat setelah kekurangan tidur (kurang dari 7 jam) selama 2 malam.

Kesimpulan: Kekurangan tidur parsial selama 2 malam menyebabkan peningkatan kadar gula darah puasa dan kadar gula darah 2 jam setelah OGTT.

Downloads

Download data is not yet available.

References

Sherwood L. Human Physiology: From Cells to Systems. 7th ed. Canada: Brooks/Cole; 2010.

Bonnet MH, Arand DL. How much sleep do adults need? [Internet]. 2007 [cited 2012 Oct 30]; Available from: http://www.sleepfoundation.org/article/white-papers/how-muchsleepdo-adults-need

National Sleep Foundation. How much sleep do we really need? [Internet]. 2010 [cited 2012 Oct 30]; Available from: http://

www.sleepfoundation.org/article/how-sleepworks/how-muchsleep-do-we-really-need

Liu X, Uchiyama M, Kim K, Okawa M, Shibui K, Kudo Y, et al. Sleep loss and daytime sleepiness in the general adult population of

Japan. Psychiatry Res. 2000;93(1):1-11.

McKnight-Eily LR, Liu Y, Wheaton AG, Croft JB, Perry GS, Okoro CA, et al. Unhealthy sleep-related behaviors-12 states, 2009. MMWR Morb Mortal Wkly Rep. 2011;60(8):233-8.

Watanabe M, Kikuchi H, Tanaka K, Takahashi M. Association of short sleep duration with weight gain and obesity at 1-year followup:

a large-scale prospective study. Sleep. 2010;33(2):161-7.

Sabanayagam C, Shankar A. Sleep duration and cardiovascular disease: Results from the National Health Interview Survey. Sleep.

;33(8):1037-42.

Gangwisch JE, Heymsfield SB, BodenAlbala B, Buijs RM, Kreier F, Pickering TG, et al . Sleep duration as a risk factor for diabetes incidence in a large US sample. Sleep. 2007;30(12):1667-73.

Mallon L, Broman JE, Hetta J. High incidence of diabetes in men with sleep complaints or short sleep duration. Diabetes Care.

;28(11):2762-7.

Nilsson PM, Roost M, Engstrom G, Hedblad B, Berglund G. Incidence of diabetes in middle-aged men is related to sleep disturbances. Diabetes Care. 2004;27(10):2464-9.

Cumberbatch CG, Younger NO, Ferguson TS, McFarlane SR, Francis DK, Wilks RJ, Tulloch-Reid MK. Reported hours of sleep, diabetes prevalence and glucose control in jamaican adults: analysis from the Jamaica lifestyle survey 2007-2008. Int J Endocrinol. 2011;2011:716214.

Chaput JP, Despres JP, Bouchard C, Tremblay A. Association of Sleep Duration with Type 2 Diabetes and Impaired Glucose

Tolerance. Diabetologia. 2007;50(11):2298-304.

Van Cauter E, Knutson KL, Leproult R, Spiegel K. The impact of sleep deprivation on hormones and metabolism. [Internet]. 2005

[cited 2013 Nov 2]. Available from: http://www.medscape.org/viewarticle/502825

Balbo M, Leproult R, Van Cauter E. Impact of sleep and its disturbances on hypothalamopituitary-adrenal axis activity. Int J Endocrinol. 2010;2010:1-16.

Knutson KL, Spiegel K, Penev P, Van Cauter E. The metabolic consequences of sleep deprivation. Sleep Med Rev. 2007;11(3):16378.

Spiegel K, Knutson KL, Leproult R, Tasali E, Van Cauter E. Sleep loss: a novel risk factor for insulin resistance and type 2 diabetes.

Japplphysiol. 2005;99(5):2008-19.

Reynolds AC, Dorrian J, Liu PY, Van Dongen HPA, Wittert GA, Harmer LJ, et al. Impact of five nights of sleep restriction on glucose

metabolism, leptin and testosterone in young adult men. PLoS One. 2012;7(7):110.

Van Cauter E, Polonsky KS, Scheen AJ. Roles of circadian rhythmicity and sleep in human glucose regulation. Endocr Rev.

;18(5):716–38

Dinneen S, Alzaid A, Miles J, Rizza R. Metabolic effects of the nocturnal rise in cortisol on carbohydrate metabolism in normal humans. J Clin Invest. 1993;92:2283-90.

Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med. 2004;141(11):846-50.

Donga E, van Dijk M, van Dijk JG, Biermasz NR, Lammers GJ, van Kralingen K, et al. A single night of partial sleep deprivation

induces insulin resistance in multiple metabolic pathways in healthy subjects. J Clin Endocrinol Metab. 2010;95(6):2963-8.

Moore MC, Coate KC, Winnick JJ, An Z, Cherrington AD. Regulation of hepatic glucose uptake and storage in vivo. Adv Nutr. 2012;3:286-94.

Morton GJ, Schwartz MW. Leptin and the central nervous system control of glucose metabolism. Physiol Rev. 2011;91(2):389411.

Rizza RA, Mandarino LJ, Gerich JE. Effects of growth hormone on insulin action in man: mechanisms of insulin resistance, impaired

suppression of glucose production, and impaired stimulation of glucose utilization. Diabetes. 1982;31(8):663-9.

Haque MS, Minokoshi Y, Hamai M, Iwai M, Horiuchi M, Shimazu T. Role of the sympathetic nervous system and insulin in enhancing

glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats. Diabetes. 1999;48(9):1706-12.

McGuinness OP, Ejiofor J, Audoly LP, Schrom N. Regulation of glucose production by NEFA and gluconeogenic precursors during

chronic glucagon infusion. Am J Physiol. 1998;275(3):432-9.

Aronoff SL, Berkowitz K, Shreiner B, Want L. Glucose metabolism and regulation: beyond insulin and glucagon. Diabetes Spectr.

;17(3):183-90.

Schmid SM, Hallschmid M, Jauch-Chara K, Wilms B, Lehnert H, Born J, et al. Disturbed glucoregulatory response to food intake

after moderate sleep restriction. Sleep. 2011;34(3):371-7.

Nedeltcheva AV, Kessler L, Imperial J, Penev PD. Exposure to recurrent sleep restriction in the setting of high caloric intake and

physical inactivity results in increased insulin resistance and reduced glucose tolerance. J Clin Endocrinol Metab. 2009;94(9):3242-50.

Published

2014-06-01

How to Cite

1.
Arieselia Z, Tasia Y, Sasmita PK. Pengaruh kurangnya jumlah jam tidur terhadap perubahan kadar gula darah pada mahasiswa preklinik Fakultas Kedokteran Unika Atma Jaya. DJM [Internet]. 2014 Jun. 1 [cited 2024 Sep. 27];13(2):128-36. Available from: https://ejournal.atmajaya.ac.id/index.php/damianus/article/view/5667
Abstract views: 26 | PDF downloads: 27