Hubungan kadar gula darah puasa dengan kadar asam urat serum pasien diabetes melitus tipe 2
DOI:
https://doi.org/10.25170/djm.v22i1.1843Keywords:
asam urat serum, diabetes melitus, gula darah puasa, inflamasi, obesitasAbstract
Pendahuluan: Penyakit kardiovaskular merupakan penyebab kematian utama (70%) pada pasien diabetes melitus tipe 2 (DMT2) sehingga kontrol glikemik yang akurat direkomendasikan untuk mencegah komplikasi kardiovaskular. Pemeriksaan Glukosa Darah Puasa (GDP) merupakan parameter kontrol glikemik sederhana dengan korelasi yang cukup kuat dengan HbA1C sebagai baku emas (r=0,61). Peningkatan asam urat serum (AUS) sebesar 1,8 mg/dL juga dapat meningkatkan risiko terhadap komplikasi makro dan mikrovaskular (28%) dan risiko mortalitas (9%) pada pasien DMT2. Tujuan dari penelitian ini adalah mengetahui hubungan antara kadar GDP sebagai parameter kontrol glikemik sederhana terhadap kadar AUS sebagai salah satu faktor risiko penyakit kardiovaskular pada pasien DMT2 di RS Atma Jaya.
Metode: Penelitian ini menggunakan pendekatan potong-lintang. Data pasien diambil dari rekam medis pasien DMT2 yang berobat di Poliklinik Cosmas Rumah Sakit (RS) Atma Jaya. Pasien yang memiliki gangguan fungsi ginjal dan mengonsumsi obat-obatan yang dapat memengaruhi kadar asam urat (seperti allopurinol) dieks-klusi.
Hasil: Jumlah pasien yang diikutkan dalam penelitian ini adalah 35 orang. Uji korelasi Pearson menemukan hubungan yang tidak signifikan antara GDP dan AUS (r=-0,101, p=0,563), namun terdapat hubungan yang signifikan antara IMT dan AUS (r=0,350, p=0,039). Uji Korelasi Spearman ditemukan hubungan yang tidak signifikan antara TD Sistolik dan AUS (r=0,145, p=0,407), TD Diastolik dan AUS (r=-0,026, p=0,884).
Simpulan: GDP, TD Sistolik, dan TD Diastolik tidak memiliki hubungan yang signifikan dengan AUS, namun IMT memiliki hubungan yang signifikan terhadap AUS pada pasien DMT2 di Poliklinik Cosmas, RS Atma Jaya.
Kata Kunci: asam urat serum, diabetes melitus, gula darah puasa, inflamasi, obesitas.
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References
Pippitt K, Li M, Gurgle HE. Diabetes mellitus: screening and diagnosis. American family physician. 2016;93(2):103-9.
World Health Organization. Diabetes fact sheets. World Health Organization. 2017. [cited 2022 Oct 1]. Available from: https://www.who.int/news-room/fact-sheets/detail/diabetes
Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan RI. Riset kesehatan dasar. Jakarta: Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan RI; 2018. [cited 2022 Oct 1]. Available from: http://repository.bkpk.kemkes.go.id/3514/1/Laporan%20Riskesdas%202018%20Nasional.pdf
Zheng Y, Ley SH, Hu FB. Global aetiology and epi-
demiology of type 2 diabetes mellitus and its com-plications. Nat. Rev. Endocrinol. 2017; 14(2):88-98.
Einarson TR, Acs A, Ludwig C, Panton UH. Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017. Cardiovascular diabetology. 2018;17(1):1-9.
Manucci E, Dicembrini I, Lauria A, Pozzilli P. Is glucose control important for prevention of cardiovascular disease in diabetes?. Diabetes Care. 2013;36(Supplement 2):S259-S263.
Yun JS, Park YM, Han K, Cha SA, Ahn YB, Ko SH. Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study. Cardiovascular Diabetology. 2019;18:1-2.
Ketema EB, Kibret KT. Correlation of fasting and postprandial plasma glucose with HbA1c in assessing glycemic control; systematic review and meta-analysis. Arch Public Health. 2015;73:43.
Zhu Y, Cong W, Shen L, Wei H, Wang Y, Wang L, et al. Fecal metabonomic study of a polysaccharide, MDG-1 from Ophiopogon japonicus on diabetic mice based on gas chromatography/time-of-flight mass spectrometry (GC TOF/MS). Mol Biosyst. 2013;10(2):309-310.
Xu Y, Zhu J, Gao L, Liu Y, Shen J, Shen C. Hyperuricemia as an independent predictor of vascular complications and mortality in type 2 diabetes patients: a meta-analysis. PLoS ONE. 2013;8(10):e78206.
Hidayat MF, Syafril S, Lindarto D. Elevated uric acid level decreases glycated hemoglobin in type 2 diabetes mellitus. Universa Medicina. 2015;33(3):199-204.
Siregar ML, Nurkhalis. Korelasi antara kadar gula darah dengan kadar asam urat pada pasien diabetes mellitus tipe 2. Idea Nursing Journal. 2015;6(3):27-33.
Romi MM, Arfian N, Tranggono U, Setyaningsih WA, Sari DC. Uric acid causes kidney injury through inducing fibroblast expansion, Endothelin-1 expression, and inflammation. BMC nephrology. 2017;18:1-8.
Buzas R, Tautu OF, Dorobantu M, Ivan V, Lighezan D. Serum uric acid and arterial hypertension - Data from Sephar III survey. PLoS ONE. 2018;13(7):e0199865.
Tsushima Y, Nishizawa H, Tochino Y, Nakatsuji H, Sekimoto R, Nagao H, et al. Uric acid secretion from adipose tissue and its increase in obesity. J. Biol. Chem. 2013;288(38):27138-49.
Ali N, Perveen R, Rahman S, Mahmood S, Islam S, Haque T, et al. Prevalence of hyperuricemia and the relationship between serum uric acid and obesity: a study on Bangladeshi adults. PLoS ONE. 2018;13(11):e0206850.
Wang H, Wang L, Xie R, Dai W, Gao C, Shen P, et al. Association of serum uric acid with body mass index: a cross-sectional study from Jiangsu Province, China. Iran. J. Public Health. 2014;43(11):1503-1509.
Seo MH, Lee WY, Kim SS, Kang JH, Kang JH, Kim KK, Kim BY, Kim YH, Kim WJ, Kim EM, Kim HS. 2018 Korean society for the study of obesity guideline for the management of obesity in Korea. Journal of obesity & metabolic syndrome. 2019 Mar;28(1):40.
Williams B, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur. Heart J. 2018;39(33):3021-3104
Wei F, Chang B, Yang X, Wang Y, Chen L, Li WD. Serum uric acid levels were dynamically coupled with hemoglobin A1c in the development of type 2 diabetes. Sci Rep. 2016;6:28549.
Hussain A, Latiwesh OB, Ali F, Younis MY, Alammari JA. Effects of body mass index, glycemic control, and hypoglycemic drugs on serum uric acid levels in type 2 diabetic patients. Cureus. 2018;10(8).
Talwar T, Tanwar L, Gupta M, Singal KK. Study of
serum uric acid levels in type 2 diabetes mellitus pa-
tients. IOSR-JDMS. 2017;16(10):83-89.
Pertiwi D, Almurdi A, Sy E. Hubungan asam urat dengan gula darah pada penderita diabetes mellitus tipe 2 yang mengalami obesitas. JKMA. 2014;8(2):79-84.
Hussain A, Latiwesh OB, Ali F, Younis MYG, Alammari JA. Effects of body mass index, glycemic control, and hypoglycemic drugs on serum uric acid levels in type 2 diabetic patients. Cureus. 2018;10(8):e3158.
Khan SA, Mandal S. Significance of serum uric acid level in prediabetic and diabetic patients. Prog Med Sci. 2018;2(2):21-26.
Wang J, Chen RP, Lei L, Song QQ, Zhang RY, Li YB, et al. Prevalence and determinants of hyperuricemia in type 2 diabetes mellitus patients with central obesity in Guangdong Province in China. Asia Pac J Clin Nutr. 2013;22(4):590-598.
Savira M, Rusdiana, Syahputra M. Association of serum uric acid level and blood pressure in type 2 diabetes mellitus. IOP Conf. Ser.: Earth Environ. Sci. 2018;125:012169.
Rafieian KM, Behradmanesh S, Kheiri S, Nasri H. Association of serum uric acid with level of blood pressure in type 2 diabetic patients. Iran J Kidney Dis. 2014;8(2):152-154.
Caliceti C, Calabria D, Roda A, Cicero AF. Fructose intake, serum uric acid, and cardiometabolic disorders: a critical review. Nutrients. 2017 Apr 18;9(4):395.
Pandey R, Humagain S, Risal P, Yadav RK, Pokhrel BR. Association between serum uric acid and blood glucose level in diabetic and non-diabetic patients. Nepal Medical College Journal. 2022;24(4):271-5.
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