Gambaran histopatologi spesimen gaster pasca laparoscopic sleeve gastrectomy di Rumah Sakit Sumber Waras, Jakarta Barat
DOI:
https://doi.org/10.25170/djm.v23i3.5488Keywords:
bedah bariatrik, gambaran histopatologi, laparoscopic sleeve gastrectomy, obesitasAbstract
Pendahuluan: Obesitas seringkali menimbulkan berbagai masalah kesehatan. Laparoscopic Sleeve Gastrectomy (LSG) merupakan pilihan terapi bagi pasien obesitas berat yang gagal dengan perubahan gaya hidup atau terapi obat. Publikasi perubahan histopatologi spesimen gaster pasca LSG masih sedikit. Tujuan penelitian ini adalah mempelajari data demografi dan gambaran histopatologi pasien yang telah menjalani LSG.
Metode: Penelitian ini adalah penelitian deskriptif potong lintang dengan jumlah sampel sebanyak 140 pasien dan berlokasi di RS Sumber Waras, Jakarta Barat, Indonesia. Variabel penelitian adalah jenis kelamin, umur, dan gambaran histopatologi. Data pasien yang menjalani LSG antara bulan Desember 2018 – Desember 2023 dikumpulkan secara purposive sampling.
Hasil: Hasil penelitian menunjukkan 140 pasien telah menjalani LSG dan diperiksa gambaran histopatologinya, perempuan 114 orang (81,4%) dan laki-laki 26 orang (18,6%). Usia penderita berkisar antara 13 hingga 67 tahun, dan sebagian besar pada kelompok usia 31-40 tahun. Histopatologi spesimen terbanyak adalah gastritis kronik sebanyak 37,2%, disusul gambaran gaster normal sebanyak 31,4%, agregat limfoid (18,6%), polip kelenjar fundus (4,3%), gastropati kongestif (2,7%), gastritis atrofik (1,6%), leiomioma (1,6%), hiperplasia kelenjar fundus (1,1%), polip inflamatorik (0,5%), divertikel (0,5%), dan neurofibroma (0,5%).
Simpulan: Gambaran histopatologi yang didapatkan pada spesimen gaster pasca LSG bervariasi dari gaster normal, lesi non neoplasma, dan neoplasma jinak yaitu leiomioma dan neurofibroma. Hasil temuan penelitian ini menunjukkan perlunya pemeriksaan histopatologi rutin pada spesimen LSG.
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References
Supriatiningrum DN. Faktor resiko wanita obesitas pada status sosial ekonomi menengah ke bawah. Ghidza Media Jurnal. 2021 Sep 20;2(2):163–8.
Kim JY. Optimal diet strategies for weight loss and weight loss maintenance. J Obes Metab Syndr. 2021 Mar 30;30(1):20–31.
Tumanggor L. Analisis pelaksanaan penanggulang-an obesitas di Polres Tapanuli Selatan tahun 2020. Nutrition and Life Journal. 2022 Sep 2;1(1):1-9.
Pojednic R, D’Arpino E, Halliday I, Bantham A. The benefits of physical activity for people with obesity, independent of weight loss: a systematic review. Int J Environ Res Public Health. 2022 Apr 20;19(9): 4981.
Johansson K, Neovius M, Hemmingsson E. Effects of anti-obesity drugs, diet, and exercise on weight-loss maintenance after a very-low-calorie diet or low-calorie diet: a systematic review and meta-analysis of randomized controlled trials123. The American Journal of Clinical Nutrition. 2014 Jan 1;99(1):14–23.
Yanovski SZ, Yanovski JA. Long-term drug treatment for obesity: a systematic and clinical review. JAMA. 2014 Jan 1;311(1):74–86.
Kang JG, Park CY. Anti-obesity drugs: a review about their effects and safety. Diabetes Metab J. 2012 Feb;36(1):13–25.
Al Saady R, Ejeckam G. Histopathological findings in laparoscopic sleeve gastrectomy specimens. Qatar Medical Journal. 2019 Sep 20;2019(1).
Bužga M, Zavadilová V, Holéczy P, Švagera Z, Švorc P, Foltys A, et al. Dietary intake and ghrelin and leptin changes after sleeve gastrectomy. Wideochir Inne Tech Maloinwazyjne. 2014 Dec; 9(4):554–61.
Giordano S, Oranges CM, Cherubino M, di Summa PG. Bariatric surgery in older adults. In: Pitchumoni CS, Dharmarajan TS, editors. Geriatric Gastroenterology. Cham: Springer International Publishing; 2020. p. 1–17.
Barski K, Binda A, Jaworski P, Gonciarska A, Kudlicka E, Żurkowska J, et al. Influence of pre-operative weight loss on gastric wall thickness—analysis of laparoscopic sleeve gastrectomy histo-logical material. Langenbecks Arch Surg. 2022 Dec 1;407(8):3315–22.
Samaan JS, Zhao J, Qian E, Hernandez A, Toubat O, Alicuben ET, et al. Preoperative weight loss as a predictor of bariatric surgery postoperative weight loss and complications. J Gastrointest Surg. 2022 Jan 1;26(1):86–93.
Saafan T, El Ansari W, Bashah M. Compared to what? Is BMI associated with histopathological changes in laparoscopic sleeve gastrectomy specimens? Obes Surg. 2019 Jul;29(7):2166-73.
Vrabie CD, Cojocaru M, Waller M, Sindelaru R, Copaescu C. The main histopathological gastric lesions in obese patients who underwent sleeve gastrectomy. Dicle Medical Journal. 2010 Mei 16; 37(2):97-103.
Clapp B. Histopathologic findings in the resected specimen of a sleeve gastrectomy. JSLS. 2015; 19(1):e2013.00259.
Miller DG. Pathology of the sleeve gastrectomy specimen. Envoi Pathology. 2016; 48(3):228-232
Yang J, Trivedi A, Nyirenda T, Shi M, Petit R, Talishinskiy T. Histopathologic findings in laparoscopic sleeve gastrectomy: Is routine full pathologic evaluation indicated? Surgery for Obesity and Related Diseases. 2023 Apr 1;19(4):283–8.
Alessandris R, Moroso F, Michelotto M, Fassan M, Angerilli V, Callegari L, et al. Preoperative endoscopy and pathology report of the specimen to be recommended in sleeve gastrectomy? Pathologica. 2023 Apr 5;115(2):90–6.
Aljerian K. Histopathological findings in laparoscopic sleeve gastrectomy specimens from patients with obesity in Saudi Arabia. Gastroenterol Res Pract. 2018 Apr 3;2018:1702705. A
Almazeedi S, Al-Sabah S, Al-Mulla A, Al-Murad A, Al-Mossawi A, Al-Enezi K, et al. Gastric histopathologies in patients undergoing laparoscopic sleeve gastrectomies. Obes Surg. 2013 Mar;23(3):314-9.
Chaudhary M, Sharma P. Abdominal obesity in India: analysis of the national family health survey-5 (2019–2021) data. The Lancet Regional Health - Southeast Asia. 2023 Jul 1;14.
Awasthi A, Panduranga AB, Deshpande A. Prevalence of overweight/obesity in South Asia: A narrative review. Clinical Epidemiology and Global Health. 2023 Jul 1;22:101316.
Giordano S, Victorzon M. Bariatric surgery in elderly patients: a systematic review. Clinical Interventions in Aging. 2015 Oct 13;10:1627–35.
Saeed S, Alothman S, Saeed K, Ahmed L, Gray S. Phlegmonous gastritis in a bariatric patient after sleeve gastrectomy. Cureus. 2019 Oct 12;
Lainas P, De Filippo G, Di Giuro G, Mikhael R, Bougneres P, Dagher I. Laparoscopic sleeve gastrectomy for adolescents under 18 years old with severe obesity. Obes Surg. 2020 Jan;30(1):267-73.
Stefura T, Skomarovska O, Wysocki M, Janik M, Krzysztofik M, Walędziak M, et al. Challenges associated with bariatric surgery – a multi-center report. Videosurgery Miniinv. 2019;14(4):526–31.
Anand S, Kalayarasan R, Chandrasekar S, Mohan P, Pottakkat B, Gnanasekaran S. Is histopathological examination of sleeve gastrectomy specimens necessary in areas endemic for gastric cancer? Natl Med J India. 2019;32(2):83.
Yamamoto S, Watabe K, Takehara T. Is obesity a new risk factor for gastritis? Digestion. 2012;85(2): 108–10.
Chakhachiro Z, Saroufim M, Safadi B, Attieh M, Assaf N, Shamseddine G, et al. Plasma cells and lymphoid aggregates in sleeve gastrectomy specimens. Medicine (Baltimore). 2020 Feb 7;99(6): e18926.
Fukayama M, Goldblum J, Miettinen M, Lazar A. WHO classification of tumours of the digestive system. 5th ed. Lyon: International Agency for Research on Cancer (IARC); 2019.
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