Deteksi molekuler high-risk human papillomavirus pada wanita berisiko tinggi di Kota Jayapura, Papua

Authors

DOI:

https://doi.org/10.25170/djm.v25i2.7725

Keywords:

DNA HR-HPV, Kota Jayapura, populasi kunci, skrining HPV

Abstract

Pendahuluan: Infeksi high-risk human papillomavirus (HR-HPV) merupakan penyebab utama kanker serviks. Data molekuler lokal pada populasi kunci di Indonesia bagian timur masih terbatas. Penelitian ini bertujuan mendeteksi DNA HR-HPV dan mendeskripsikan distribusi HPV 16, HPV 18, dan HR-HPV non-16/18 pada wanita pekerja seks (WPS) di Kota Jayapura.

Metode: Studi potong lintang ini melibatkan 30 WPS. Swab serviks diperiksa dengan real-time polymerase chain reaction (qPCR) menggunakan assay yang mendeteksi HPV 16 dan HPV 18 secara terpisah serta melaporkan 12 genotipe HR-HPV lain sebagai kelompok gabungan non-16/18. Karakteristik responden dianalisis secara deskriptif.

Hasil: DNA HR-HPV terdeteksi pada 10 dari 30 responden (33,3%). Seluruh hasil positif berada pada kelompok non-16/18, sedangkan HPV 16 dan HPV 18 tidak terdeteksi. Sebanyak 25 responden (83,3%) belum pernah menerima vaksin HPV dan 15 responden (50,0%) melaporkan tidak pernah menggunakan kondom.

Kesimpulan: HR-HPV terdeteksi pada sepertiga responden dan seluruh hasil positif termasuk kelompok non-16/18. Temuan ini mendukung penggunaan skrining DNA HPV yang mampu mendeteksi spektrum HR-HPV secara luas dan layanan pencegahan terintegrasi. Interpretasi temuan dibatasi oleh ukuran sampel purposif yang kecil serta keterbatasan uji dalam mengidentifikasi genotipe individual non-16/18.

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Author Biographies

  • Eka Dian Ayu Agustina Fatem, Unversitas Cenderawasih

    I am a clinical microbiologist and lecturer at the Microbiology Department, Faculty of Medicine, Universitas Cenderawasih, Jayapura, Indonesia. My work focuses on clinical diagnostics, laboratory development, and teaching in infectious diseases. I am particularly interested in tuberculosis, antimicrobial resistance, and molecular diagnostics, with an emphasis on improving laboratory capacity and patient care in resource-limited settings.

  • Grace Fitriana Primasari Hau Mahu, Faculty of Medicine, Universitas Cenderawasih

    Grace is a professional lecturer  (Assistant Professor) in the Department of Tropical Medicine at the Faculty of Medicine, Universitas Cenderawasih. Academic work focuses on Tropical Medicine

  • Elisa Nugraha Haryadi Salakay

    Elisa NHS is a professional in medical education and a Assisstant Professor affiliated with Cenderawasih University. His work primarily focuses on medical and health professions education, with interests in learning resource development, e-learning, assessment, and clinical teaching.

  • Dais Iswanto, Faculty of Medicine, Universitas Cenderawasih
    Dais Iswanto adalah Pranata Laboratorium Pendidikan di Fakultas Kedokteran Universitas Cenderawasih.
  • Nuraliah Rusman, Faculty of Medicine, Universitas Cenderawasih

    Nuraliah Rusman is a Laboratory Staff at the Faculty of Medicine

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Published

2026-08-31

Issue

Vol. 25 No. 2 (2026): Damianus Journal of Medicine

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Articles

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How to Cite

1.
Fatem EDAA, Hau Mahu GFP. Deteksi molekuler high-risk human papillomavirus pada wanita berisiko tinggi di Kota Jayapura, Papua. DJM [Internet]. 2026 Aug. 31 [cited 2026 Sep. 11];25(2):175-86. Available from: https://ejournal.atmajaya.ac.id/index.php/damianus/article/view/7725