Effect of Avocado Seed Extract through Milling on Reducing Triglyceride in Hyperlipidemic Rats

Authors

  • Rita Dewi Department of Chemistry and Biochemistry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia
  • Jojor Lamsihar Manalu Departement of Physiology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.
  • Yulia Tanti Department of Microbiology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.
  • Maria Dara Department of Chemistry and Biochemisty, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.
  • Alexander Yose School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.

DOI:

https://doi.org/10.25170/juhr.v1i3.4617

Abstract

Background : Hypertriglyceridemia is a condition in which there is an increase in triglycerides in the blood. This increase is influenced by foods that contain extra calories. Hypertriglyceridemia can cause disturbances in the body in the form of cardiovascular disease.

Methods : The study used experimental methods on male Sprague Dawley rats. The research sample used fourteen rats which were divided into a control group and a treatment group. All experimental mice were induced to become hyperlipidemic by PTU14 gram/kg for 14 day. The control group was not given any treatment. The treatment group was given avocado seed extract 250 mg/kg for 14 day. Avocado seed extract is obtained through crushing and extraction processes. The statistic we used in this study is paired T-test.

Results : In the control group, there was no decrease in triglyceride levels with an average of 134.78 mg / dL. In the treatment group there was a decrease in the average triglyceride levels both after seven days of giving avocado seed extract on (day 28) 127.92 md / dL and after fourteen days of giving avocado seed extract on (day 35) 124.21 mg / dL.

Conclusion: Giving of avocado seed extract by grinding method for 30 minutes selama sekian hari had an effect in reducing triglyceride levels in hyperlipidemic rats.

Keywords: Avocado Seed Extract - Sprague Dawley Rats - Triglyceride Level.

Author Biographies

Rita Dewi, Department of Chemistry and Biochemistry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Lecturer at Department of Chemistry and Biochemistry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, North Jakarta, Indonesia

Jojor Lamsihar Manalu, Departement of Physiology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.

Lecturer at Department of Physiology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.
Lecturer at Master Program in Biomedical Sciences, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.
Lecturer at Master Program in Electrical Engineering, Faculty of Engineering, Atma Jaya Catholic University of Indonesia.

Yulia Tanti, Department of Microbiology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.

Lecturer at Department of Microbiology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.
Lecturer at Master Program in Biomedical Sciences, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.

Maria Dara, Department of Chemistry and Biochemisty, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.

Lecturer at Department of Chemistry and Biochemistry School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.
Lecturer at Master Program in Biomedical Sciences School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.

Alexander Yose , School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.

Student at  School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia.

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Published

2023-08-11

How to Cite

1.
Firmansyah RD, Manalu JL, Narwati YT, Handayani MDN, Sulistyo AYAB. Effect of Avocado Seed Extract through Milling on Reducing Triglyceride in Hyperlipidemic Rats. j. urban health res. [Internet]. 2023 Aug. 11 [cited 2024 Nov. 24];1(3):37-43. Available from: https://ejournal.atmajaya.ac.id/index.php/juhr/article/view/4617
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