Pharmacogenomic Role in Cytochrome P450 Enzymes-Mediated Metabolism for Drug Therapy

Authors

  • Lonah Department of Pharmacology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • Zita Arieselia Department of Pharmacology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • Jonny Setiawan Department of Surgery, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • Rita Dewi Department of Chemistry and Biochemistry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • Maria Dara Novi Handayani Department of Chemistry and Biochemistry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
  • Linawati Hananta Department of Pharmacology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

DOI:

https://doi.org/10.25170/juhr.v1i3.4629

Keywords:

Adverse Drug Reactions (ADRs), Genetic variants, Pharmacogenomics (PGx)

Abstract

The rapid development of genetic science in recent decades has provided opportunities for clinical implementation. In the field of pharmacology, this opens up hope for the use of more targeted drugs with fewer side effects.Genetic variation's influence on pharmacological response has been well-established in practice. Patients' responses to pharmacological therapies can be varied, ranging from positive effects to serious adverse drug reactions (ADRs). Numerous genetic variations have been found to have a major impact on how people react to routinely prescribed medications over time, according to experts. In order to use this genetic information to inform treatment choices, a pharmacogenomic (PGx) profile can be used. PGx works on identifying and validating genomic variations that affect drug response. The generic approach to healthcare has given way to a more individualized and precise treatment paradigm as it has developed.

Keywords: Adverse Drug Reactions - Genetic Variants – Pharmacogenomics - Cytochrome P450

Author Biographies

Lonah, Department of Pharmacology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

 

 

 

 

Zita Arieselia, Department of Pharmacology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

 

 

 

 

Jonny Setiawan, Department of Surgery, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

 

 

 

Rita Dewi, Department of Chemistry and Biochemistry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

 

 

 

Maria Dara Novi Handayani, Department of Chemistry and Biochemistry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia

 

 

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Published

2023-08-20

How to Cite

1.
Lonah, Arieselia Z, Setiawan J, Dewi R, Dara Novi Handayani M, Hananta L. Pharmacogenomic Role in Cytochrome P450 Enzymes-Mediated Metabolism for Drug Therapy. j. urban health res. [Internet]. 2023 Aug. 20 [cited 2024 Dec. 3];1(3):44-56. Available from: https://ejournal.atmajaya.ac.id/index.php/juhr/article/view/4629

Issue

Vol. 1 No. 3 (2023): Journal of Urban Health Research

Section

Article

License

Copyright (c) 2023 Lonah, Zita Arieselia, Jonny Setiawan, Rita Dewi, Maria Dara Novi Handayani

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

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